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- $Unique_ID{BRK03075}
- $Pretitle{}
- $Title{chlorambucil}
- $Subject{Leukeran Burroughs Wellcome Antineoplastic anticancer drug
- chlorambucil alkylating agents cancers binding cancer cells}
- $Volume{}
- $Log{}
-
- Copyright (C) 1993 Publications International, Ltd.
-
-
- chlorambucil
- ------------------------------------------------------------------------------
-
- BRAND NAME (Manufacturer)
-
- Leukeran (Burroughs Wellcome)
-
- TYPE OF DRUG
-
- Antineoplastic (anticancer drug)
-
- INGREDIENT
-
- chlorambucil
-
- DOSAGE FORM
-
- Tablets (2 mg)
-
- STORAGE
-
- Chlorambucil should be stored at room temperature in a tightly closed,
- light-resistant container.
-
- USES
-
- Chlorambucil belongs to a group of drugs known as alkylating agents. It
- is used to treat a variety of cancers. Chlorambucil works by binding to the
- rapidly growing cancer cells, preventing their multiplication and growth.
-
- TREATMENT
-
- Chlorambucil can be taken either on an empty stomach or with food or milk
- (as directed by your doctor).
- The timing of the doses of this medication is important. Be sure you
- completely understand your doctor's instructions on how this medication should
- be taken.
- If you miss a dose of this medication, take the missed dose as soon as
- possible, unless it is almost time for the next dose. In that case, do not
- take the missed dose at all; just return to your regular dosing schedule. Do
- not double the next dose.
-
- SIDE EFFECTS
-
- Minor.
-
- Nausea, stomach upset, or vomiting. These side effects may disappear as
- your body adjusts to this medication. It is important, however, to continue
- taking this medication despite any nausea and vomiting that may occur.
- Chlorambucil can also cause hair loss, which is reversible when the
- medication is stopped.
-
- Major.
-
- Tell your doctor about any side effects that are persistent or
- particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
- chills, convulsions, difficulty in breathing, fever, itching, joint pain,
- menstrual irregularities, mouth sores, skin rash, sore throat, unusual
- bleeding or bruising, or yellowing of the eyes or skin.
-
- INTERACTIONS
-
- Chlorambucil can increase the blood levels of uric acid, which can block
- the effectiveness of antigout medications (allopurinol, probenecid,
- sulfinpyrazone).
- BE SURE TO TELL YOUR DOCTOR about any medications you are currently
- taking, especially any listed above.
-
- WARNINGS
-
- * Tell your doctor about unusual or allergic reactions you have had to
- any drugs, especially to chlorambucil or melphalan.
- * Before starting to take this medication, be sure to tell your doctor if
- you now have or if you have ever had blood disorders, chronic or recurrent
- infections, gout, kidney stones, or seizures.
- * You should not receive any immunizations or vaccinations while taking
- this medication. Chlorambucil blocks the effectiveness of the vaccine and may
- lead to overwhelming infection if a live-virus vaccine is administered.
- * While you are taking this medication, it is important that you drink
- plenty of fluids to prevent the formation of uric acid kidney stones.
- * Chlorambucil can lower your platelet count, which can decrease your
- body's ability to form blood clots. You should, therefore, be especially
- careful while brushing your teeth, flossing, or using toothpicks, razors, or
- fingernail scissors. Try to avoid falls and other injuries. Before having
- any surgery or other medical or dental treatment, be sure that your doctor or
- dentist knows that you are taking this medication.
- * Chlorambucil can decrease fertility in both sexes.
- * Be sure to tell your doctor if you are pregnant. Birth defects have
- been reported in both animals and humans whose mothers received chlorambucil
- during pregnancy. The risks should be discussed with your doctor. Also, tell
- your doctor if you are breast-feeding an infant. It is not known whether or
- not chlorambucil passes into breast milk.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-